After accepting an invitation from a mysterious trainer, Ash, Misty and Brock meet Mewtwo, an artificially created Pokémon who wants to do battle.

The Team Rocket leader, Giovanni, has found Mewtwo in a remote area of the Johto region. As Giovanni tries to re-capture Mewtwo, Ash and his friends are kidnapped by Domino, a new Team Rocket member, while trying to rescue Pikachu from Jessie and James. The Clone Pokemon are also captured and are then used as bait for Mewtwo. The situation then becomes a battle between the wills of Mewtwo and Giovanni; and Mewtwo also tries to discover if it and the clones have a purpose in life, even though they are products of science.

Mewtwo - Prologue to Awakening is a special episode of the Pokémon anime, serving as a prologue to Genesect and the Legend Awakened.

Determined to prove its superiority, a bio-engineered Pokémon called Mewtwo lures Ash, Pikachu and others into a Pokemon match like none before.

When the sadness of her father's disappearance gets to Molly Hale, she unknowingly uses the Unown to create her own dream world along with Entei, who she believes to be her father. When Entei kidnaps Ash's mother, Ash — alongside Misty and Brock — invade the mansion looking for his mom and trying to stop the mysteries of Molly's Dream World and Entei!

Ash Ketchum wakes up late one morning after having broken his alarm clock in his sleep. He eventually makes it to Professor Oak's lab, but is told that the three starter List of Pokémon (Bulbasaur, Squirtle, and Charmander) have already been taken by Trainers who were on time. However, Oak reveals that he has one more Pokémon, an Electric-type named Pikachu. Despite its volatile and feisty personality, as well as its refusal to get inside a Poké Ball, Ash happily takes Pikachu for his journey.

In the Forest of Okoya, Koko is a feral child who has been raised as a Pokémon by the Mythical Pokémon Zarude. Koko has grown up never doubting that he is a Pokémon even though he can't really use any sort of moves. Ash Ketchum and Pikachu meet Koko and help him protect the Great Tree from the crooked scientist Dr. Zed.

A young athlete whose running days might be behind her, a compulsive liar, a shy researcher, a bitter old woman, and a little girl with a big secret—the only thing they have in common is the annual Wind Festival in Fula City. The festival celebrates the Legendary Pokémon Lugia, who brings the wind that powers this seaside city. When a series of threats endangers not just the festival, but all the people and Pokémon of Fula City, it’ll take more than just Satoshi and Pikachu to save the day! Can everyone put aside their differences and work together—or will it all end in destruction?

The Kingdom of the People of the Earth once ruled over the land, but now all that remains is the Sword of the Earth. in the city of Eindoak. Satoshi, Iris, and Dent arrive in Eindoak during a harvest festival's Pokémon Tournament and meet the legendary Pokémon Victini who wishes to share its powers of victory to someone. Elsewhere in the city, a descendant of the People of the Earth named Dred Grangil has arrived who seeks to revive the kingdom's power with the Sword of the Earth, bringing them back into power over the land, and Satoshi and his friends must stop him before he destroys the land along with Victini.

Ash meets the Mythical Pokémon Volcanion when it crashes down from the sky, creating a cloud of dust—and a mysterious force binds the two of them together! Volcanion despises humans and tries to get away, but it’s forced to drag Ash along as it continues its rescue mission. They arrive in a city of cogs and gears, where a corrupt official has stolen the ultimate invention: the Artificial Pokémon Magearna, created 500 years ago. He plans to use its mysterious power to take control of this mechanical kingdom! Can Ash and Volcanion work together to rescue Magearna? One of the greatest battles in Pokémon history is about to unfold!